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Cat. No. | Product Name | Target | Signaling Pathways |
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T15942 |
MK-7622
M1 receptor modulator |
AChR | Neuroscience |
MK-7622 (M1 receptor modulator) 是毒蕈碱 M1 受体阳性变构的调节剂。 | |||
T7002 |
Trihexyphenidyl hydrochloride
Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride,盐酸苯海索 |
AChR | Neuroscience |
Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) 是一种抗毒蕈碱类的抗帕金森病药物,结合至M1毒蕈碱受体。 | |||
T1049 |
Oxybutynin chloride
Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl |
Potassium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Oxybutynin chloride (Oxybutynin HCl) 是一种抗胆碱能药物,用于缓解泌尿和膀胱困难。它抑制血管 Kv 通道,IC50为 11.51 μM。 | |||
T8219 |
VU0238441
|
AChR | Neuroscience |
VU0238441是一种泛毒蕈碱型乙酰胆碱受体阳性变构调节剂,对 M1、M2、M3、M5 和 M4 的EC50分别为 3.2、2.8、2.2、2.1 和大于 10 μM。 | |||
T1475 |
Fesoterodine fumarate
Toviaz,SPM 907,富马酸非索罗定 |
AChR | Neuroscience |
Fesoterodine fumarate (Toviaz) 是可口服的,非亚型选择性的竞争性毒蕈碱受体拮抗剂,用于膀胱过度活动症,对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。 | |||
T24469 |
MIPS1455
MIPS-1455,MIPS 1455 |
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MIPS1455 is a photoactivatable allosteric M1 muscarinic acetylcholine receptor ligand. | |||
T27961 |
LY593093
LY 593093,LY-593093 |
||
LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor. | |||
T16758 | Rispenzepine | Others | Others |
Rispenzepine 是一种新型的毒蕈碱型乙酰胆碱受体(mAChRs)的拮抗剂,选择性地靶向M1 和 M3 受体亚型,可用于治疗免疫系统疾病、感染、呼吸系统疾病。 | |||
T60728 |
M1 ligand 1
|
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M1 ligand 1 (compound 3b-b) 是槟榔碱衍生物的 N- 去甲基同源物,是毒蕈碱乙酰胆碱受体 M1 的配体。M1 ligand 1 用作正电子发射断层扫描(PET)的放射性示踪剂。 | |||
T17245 |
VU0467485
AZ13713945 |
Others | Others |
VU0467485 is a potent and selective muscarinic acetylcholine receptor 4 positive allosteric modulator. VU0467485 potentiates the activity of ACh at M4 (EC50s: 26.6 nM and 78.8 nM at the rat and human M4 receptors, respectively). VU0467485 displays selecti | |||
T23763 |
Atropine Oxide
NSC 72861,NSC72861,NSC-72861 |
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Atropine Oxide is a derivative of Atropine. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5. Atropine is a medication to treat certain types of nerve agents and pesticide poisonings as well as som | |||
T61228 |
Pirenzepine
|
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Pirenzepine (LS 519 free base) is a selective antagonist of the M1 muscarinic acetylcholine receptor (mAChR). It effectively inhibits gastric acid secretion and reduces muscle spasm, making it a valuable compound for investigating peptic ulcers. Additionally, Pirenzepine exhibits anti-proliferative activity against cancer cells [1] [2]. | |||
T37728 | Methoctramine (hydrate) | ||
Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2] In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs wit... | |||
T69232 |
Atropine Oxide Hydrochloride
|
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Atropine Oxide is a derivative of Atropine. Atropine is a medication to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate and to decrease saliva production during surgery. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. It is classified as an anticholinergic drug (parasympatholytic). | |||
T60577 |
Cycrimine
|
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Cycrimine 是毒蕈碱胆碱能受体(mAChR)M1的口服活性拮抗剂,可降低帕金森模型中乙酰胆碱的水平。Cycrimine 具有解痉活性,可用于研究行为和精神障碍。 | |||
T38895 |
Zanapezil free base
TAK-147 free base,Zanapezil free base |
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Zanapezil (TAK-147) is a powerful and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant and reversible inhibition of AChE activity in rat cerebral cortex homogenates (IC50 = 51.2 nM). Furthermore, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. This compound holds promise for the investigation of the initial stages of Alzheimer's disease (AD). | |||
T36241 |
Arecaidine propargyl ester (hydrobromide)
|
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Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecai... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN1653 |
Fustin
|
ERK; Beta Amyloid; AChR | MAPK; Neuroscience |
Fustin 是植物漆树 (Rhus verniciflua Stokes) 的植物性黄烷醇成分。 Fustin 对 6-羟基多巴胺诱导的神经元细胞死亡具有保护作用。 |
Cat. No. | Product Name | Species | Expression System |
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TMPH-03338 |
CHRM1 Protein, Rat, Recombinant (His)
Muscarinic acetylcholine receptor... |
Rat | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.1 kDa and the accession number is P08482. | |||
TMPH-01714 |
CHRM1 Protein, Human, Recombinant (His)
Muscarinic acetylcholine receptor... |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P11229. |